Aquaporin 5 in the eye: Expression, function, and roles in ocular diseases

As a water channel protein, aquaporin 5 (AQP5) is essential for the maintenance of the normal physiological functions of ocular tissues. This review provides an overview of the expression and function of AQP5 in the eye and discusses their role in related eye diseases. Although AQP5 plays a vital ro...

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Veröffentlicht in:Experimental eye research 2023-08, Vol.233, p.109557-109557, Article 109557
Hauptverfasser: Zhang, Kaier, Di, Guohu, Bai, Ying, Liu, Anxu, Bian, Wenhan, Chen, Peng
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Sprache:eng
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Zusammenfassung:As a water channel protein, aquaporin 5 (AQP5) is essential for the maintenance of the normal physiological functions of ocular tissues. This review provides an overview of the expression and function of AQP5 in the eye and discusses their role in related eye diseases. Although AQP5 plays a vital role in ocular functions, such as maintaining corneal and lens transparency, regulating water movement, and maintaining homeostasis, some of its functions in ocular tissues are still unclear. Based on the key role of AQP5 in eye function, this review suggests that in the future, eye diseases may be treated by regulating the expression of aquaporin. •Aquaporin 5 plays an important role in the normal physiological function of the eye.•Changes in aquaporin 5 expression are associated with ocular surface diseases.•Aquaporin 5 may be a potential target for drug treatment of ocular surface diseases.
ISSN:0014-4835
1096-0007
DOI:10.1016/j.exer.2023.109557