Enabling a universal lateral flow readout for DNA strand displacement via disassembling chemical labels

Herein, we describe a novel strategy that enables lateral flow readout for DNA strand displacement disassembling chemical labels (DCL). Comparing it to a classic fluorogenic assay, we demonstrate that our DCL-based lateral flow assay is highly sensitive and specific, capable of discriminating single...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2023-07, Vol.59 (57), p.8803-8805
Hauptverfasser:	Peng, Wanting, Tan, Yun, Shen, Chenlan, Tang, Yanan, Li, Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Dismantling Labels Nucleotides
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Herein, we describe a novel strategy that enables lateral flow readout for DNA strand displacement disassembling chemical labels (DCL). Comparing it to a classic fluorogenic assay, we demonstrate that our DCL-based lateral flow assay is highly sensitive and specific, capable of discriminating single nucleotide variants in buccal swab samples.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/d3cc01743e