Exploring the molecular characteristics of the malignant potential of gastric adenocarcinoma with enteroblastic differentiation

Exploring the molecular characteristics of the malignant potential of gastric adenocarcinoma with enteroblastic differentiation

Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare subset of alpha-fetoprotein (AFP)-producing carcinomas with poor prognosis. However, the molecular features associated with the malignant potential of GEAD remain partially elucidated. In this study, the relationship between...

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Veröffentlicht in:Histopathology 2023-10, Vol.83 (4), p.631-646
Hauptverfasser: Wang, Yong, Wei, Xiyin, Ke, Bin, Liu, Jia, Guo, Yuhong, Liu, Yanxue, Chen, Yongzi, Ding, Tingting, Wang, Yalei, Meng, Bin, Sun, Baocun, Zang, Fenglin
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma
Aggressive behavior
Apoptosis
Cell death
ErbB-2 protein
Gastric cancer
Genomic instability
Hepatocellular carcinoma
Hybridization
Liver cancer
Metastases
Mismatch repair
Mutation
p53 Protein
PD-L1 protein
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Zusammenfassung:Gastric adenocarcinoma with enteroblastic differentiation (GAED) is a rare subset of alpha-fetoprotein (AFP)-producing carcinomas with poor prognosis. However, the molecular features associated with the malignant potential of GEAD remain partially elucidated. In this study, the relationship between clinicopathological parameters and aggressive biological behaviour was analysed in 37 patients with GAED. The results showed that GAED tended to infiltrate the deep layer of the gastric wall and possessed more frequent vascular invasion than conventional gastric adenocarcinoma (CGA) (P 
ISSN:0309-0167
1365-2559
DOI:10.1111/his.14998