European Association of Urology Biochemical Recurrence Risk Classification as a Decision Tool for Salvage Radiotherapy—A Multicenter Study

Improved survival within the high-risk biochemical recurrence (BCR) group for patients treated with early salvage radiotherapy (SRT) compared with those under observation was recorded. Men with low-risk BCR had favorable long-term outcome. Our results suggest recommending early SRT for high-risk BCR men. Conversely, surveillance only might be suitable for low-risk BCR. The European Association of Urology (EAU) has proposed a risk stratification for patients harboring biochemical recurrence (BCR) after radical prostatectomy (RP). To assess whether this risk stratification helps in choosing patients for salvage radiotherapy (SRT). Analyses of 2379 patients who developed BCR after RP (1989–2020), within ten European high-volume centers, were conducted. Early and late SRT were defined as SRT delivered at prostate-specific antigen values