Expanding the Substrate Scope of Acyltransferase LovD9 for the Biosynthesis of Statin Analogues

Invited for the cover of this issue are the groups of Gonzalo Jiménez‐Osés and Fernando López‐Gallego at CIC bioGUNE and CIC biomaGUNE, respectively. The image depicts the substrate scope of an engineered acyl transferases for the synthesis of statin derivatives. Read the full text of the article at 10.1002/chem.202300911. “The most exciting result is the ability of LovD9 acyl transferase to bind acyl donors with different Michaelis–Menten kinetics and selectivity properties that have an impact on the final product yield and reaction rate.” This and more about the story behind the front cover can be found in the article at 10.1002/chem.202300911).