The antioxidant/anti‐inflammatory protective effects of rutin against ethanol‐induced testicular perturbation in rats: Involvement of the immunosuppressive indoleamine 2,3‐dioxygenase
This study investigated the influence of rutin against EtOH‐induced testicular impairment in rats and the involvement of the indole‐aminergic pathway. Four groups of eight rats each were orally exposed to drinking water (Group 1), EtOH (5 g/kg bwt, Group 2), R (5 g/kg bwt, Group 3), and EtOH + R (5 ...
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| Veröffentlicht in: | Basic & clinical pharmacology & toxicology 2023-09, Vol.133 (3), p.254-264 |
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| creator | Ebokaiwe, Azubuike Peter Obasi, Doris Olachi Osawe, Sharon Oluchi Njoku, Rex Clovis C. |
| description | This study investigated the influence of rutin against EtOH‐induced testicular impairment in rats and the involvement of the indole‐aminergic pathway. Four groups of eight rats each were orally exposed to drinking water (Group 1), EtOH (5 g/kg bwt, Group 2), R (5 g/kg bwt, Group 3), and EtOH + R (5 g/kg bwt + 50 mg/kg bwt, Group 4) via gavage for 15 days. Results showed that exposure to EtOH significantly (p |
| doi_str_mv | 10.1111/bcpt.13919 |
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Four groups of eight rats each were orally exposed to drinking water (Group 1), EtOH (5 g/kg bwt, Group 2), R (5 g/kg bwt, Group 3), and EtOH + R (5 g/kg bwt + 50 mg/kg bwt, Group 4) via gavage for 15 days. Results showed that exposure to EtOH significantly (p < 0.0001) reduced the testicular antioxidant system and increased lipid peroxidation (LPO) relative to control. We observed a significant (p < 0.0001) increase in the inflammatory biomarkers, with attendant disruption in the testicular histological structure and concomitant elevation in the activities of indoleamine 2,3‐dioxygenase (IDO), in comparison with control and no noticeable effects in tryptophan 2,3‐dioxygenase (TDO) activity across the groups. Rutin‐only exposed group did not show any alteration in the measured parameters when compared with the control. Rutin co‐exposure augmented the antioxidant system, prevented histological damage, reduced LPO and inflammation, and thus, lowered EtOH‐mediated increase in IDO activity, compared with control. Overall, these findings reveal the involvement of the indole‐aminergic pathway in rutin's protective influence against EtOH‐induced testicular impairment in rats.</description><identifier>ISSN: 1742-7835</identifier><identifier>EISSN: 1742-7843</identifier><identifier>DOI: 10.1111/bcpt.13919</identifier><identifier>PMID: 37350278</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>alcohol ; Antioxidants ; Biomarkers ; Damage prevention ; Dioxygenase ; Drinking behavior ; Drinking water ; Ethanol ; Exposure ; Impairment ; indoleamine 2,3‐dioxygenase ; Inflammation ; Lipid peroxidation ; Lipids ; male rats ; oxidative‐inflammatory stress ; Peroxidation ; Perturbation ; Rutin ; Testes ; Tryptophan</subject><ispartof>Basic & clinical pharmacology & toxicology, 2023-09, Vol.133 (3), p.254-264</ispartof><rights>2023 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd</rights><rights>2023 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3169-72b25fd1a7ae1709a6b372bc23c08b1c659f1256419375d0da7a2cb99c7ef233</cites><orcidid>0000-0003-2826-4844</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fbcpt.13919$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fbcpt.13919$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37350278$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ebokaiwe, Azubuike Peter</creatorcontrib><creatorcontrib>Obasi, Doris Olachi</creatorcontrib><creatorcontrib>Osawe, Sharon Oluchi</creatorcontrib><creatorcontrib>Njoku, Rex Clovis C.</creatorcontrib><title>The antioxidant/anti‐inflammatory protective effects of rutin against ethanol‐induced testicular perturbation in rats: Involvement of the immunosuppressive indoleamine 2,3‐dioxygenase</title><title>Basic & clinical pharmacology & toxicology</title><addtitle>Basic Clin Pharmacol Toxicol</addtitle><description>This study investigated the influence of rutin against EtOH‐induced testicular impairment in rats and the involvement of the indole‐aminergic pathway. Four groups of eight rats each were orally exposed to drinking water (Group 1), EtOH (5 g/kg bwt, Group 2), R (5 g/kg bwt, Group 3), and EtOH + R (5 g/kg bwt + 50 mg/kg bwt, Group 4) via gavage for 15 days. Results showed that exposure to EtOH significantly (p < 0.0001) reduced the testicular antioxidant system and increased lipid peroxidation (LPO) relative to control. We observed a significant (p < 0.0001) increase in the inflammatory biomarkers, with attendant disruption in the testicular histological structure and concomitant elevation in the activities of indoleamine 2,3‐dioxygenase (IDO), in comparison with control and no noticeable effects in tryptophan 2,3‐dioxygenase (TDO) activity across the groups. Rutin‐only exposed group did not show any alteration in the measured parameters when compared with the control. Rutin co‐exposure augmented the antioxidant system, prevented histological damage, reduced LPO and inflammation, and thus, lowered EtOH‐mediated increase in IDO activity, compared with control. Overall, these findings reveal the involvement of the indole‐aminergic pathway in rutin's protective influence against EtOH‐induced testicular impairment in rats.</description><subject>alcohol</subject><subject>Antioxidants</subject><subject>Biomarkers</subject><subject>Damage prevention</subject><subject>Dioxygenase</subject><subject>Drinking behavior</subject><subject>Drinking water</subject><subject>Ethanol</subject><subject>Exposure</subject><subject>Impairment</subject><subject>indoleamine 2,3‐dioxygenase</subject><subject>Inflammation</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>male rats</subject><subject>oxidative‐inflammatory stress</subject><subject>Peroxidation</subject><subject>Perturbation</subject><subject>Rutin</subject><subject>Testes</subject><subject>Tryptophan</subject><issn>1742-7835</issn><issn>1742-7843</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAQxy0EoqVw4QGQJS4IsW1sJ-u4N1jxUakSHPYeOc6kdeXYwR8Le-MReCFehidh0i09cMCXmbF-85-x_4Q8Z9Upw3PWmzmfMqGYekCOmaz5Sra1eHifi-aIPEnppqq4rFn1mBwJKRos2mPya3sNVPtsw3c7YDxb8t8_flo_Oj1NOoe4p3MMGUy2O6AwjpglGkYaS7ae6ittfcoU8rX2wd22DsXAQDOkbE1xOtIZYi6x1zjGU2yKOqdzeuF3we1gAp8XvYyb2GkqPqQyzxFSWgaiWnCgJ-uB8jcC9QfcdX8FXid4Sh6N2iV4dhdPyPbD--3m0-ry88eLzdvLlRFsrVaS97wZB6alBiYrpde9wDvDhananpl1o0bGm3XNlJDNUA0IctMrZSSMXIgT8uogix_xteCzuskmA85pD6Gkjrdc1YJVnCP68h_0JpTocTmkaiWlqFWL1OsDZWJIKcLYzdFOOu47VnWLp93iaXfrKcIv7iRLP8Fwj_41EQF2AL5ZB_v_SHXvNl-2B9E_0QO0rg</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Ebokaiwe, Azubuike Peter</creator><creator>Obasi, Doris Olachi</creator><creator>Osawe, Sharon Oluchi</creator><creator>Njoku, Rex Clovis C.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2826-4844</orcidid></search><sort><creationdate>202309</creationdate><title>The antioxidant/anti‐inflammatory protective effects of rutin against ethanol‐induced testicular perturbation in rats: Involvement of the immunosuppressive indoleamine 2,3‐dioxygenase</title><author>Ebokaiwe, Azubuike Peter ; Obasi, Doris Olachi ; Osawe, Sharon Oluchi ; Njoku, Rex Clovis C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3169-72b25fd1a7ae1709a6b372bc23c08b1c659f1256419375d0da7a2cb99c7ef233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>alcohol</topic><topic>Antioxidants</topic><topic>Biomarkers</topic><topic>Damage prevention</topic><topic>Dioxygenase</topic><topic>Drinking behavior</topic><topic>Drinking water</topic><topic>Ethanol</topic><topic>Exposure</topic><topic>Impairment</topic><topic>indoleamine 2,3‐dioxygenase</topic><topic>Inflammation</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>male rats</topic><topic>oxidative‐inflammatory stress</topic><topic>Peroxidation</topic><topic>Perturbation</topic><topic>Rutin</topic><topic>Testes</topic><topic>Tryptophan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ebokaiwe, Azubuike Peter</creatorcontrib><creatorcontrib>Obasi, Doris Olachi</creatorcontrib><creatorcontrib>Osawe, Sharon Oluchi</creatorcontrib><creatorcontrib>Njoku, Rex Clovis C.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Basic & clinical pharmacology & toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ebokaiwe, Azubuike Peter</au><au>Obasi, Doris Olachi</au><au>Osawe, Sharon Oluchi</au><au>Njoku, Rex Clovis C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The antioxidant/anti‐inflammatory protective effects of rutin against ethanol‐induced testicular perturbation in rats: Involvement of the immunosuppressive indoleamine 2,3‐dioxygenase</atitle><jtitle>Basic & clinical pharmacology & toxicology</jtitle><addtitle>Basic Clin Pharmacol Toxicol</addtitle><date>2023-09</date><risdate>2023</risdate><volume>133</volume><issue>3</issue><spage>254</spage><epage>264</epage><pages>254-264</pages><issn>1742-7835</issn><eissn>1742-7843</eissn><abstract>This study investigated the influence of rutin against EtOH‐induced testicular impairment in rats and the involvement of the indole‐aminergic pathway. Four groups of eight rats each were orally exposed to drinking water (Group 1), EtOH (5 g/kg bwt, Group 2), R (5 g/kg bwt, Group 3), and EtOH + R (5 g/kg bwt + 50 mg/kg bwt, Group 4) via gavage for 15 days. Results showed that exposure to EtOH significantly (p < 0.0001) reduced the testicular antioxidant system and increased lipid peroxidation (LPO) relative to control. We observed a significant (p < 0.0001) increase in the inflammatory biomarkers, with attendant disruption in the testicular histological structure and concomitant elevation in the activities of indoleamine 2,3‐dioxygenase (IDO), in comparison with control and no noticeable effects in tryptophan 2,3‐dioxygenase (TDO) activity across the groups. Rutin‐only exposed group did not show any alteration in the measured parameters when compared with the control. Rutin co‐exposure augmented the antioxidant system, prevented histological damage, reduced LPO and inflammation, and thus, lowered EtOH‐mediated increase in IDO activity, compared with control. Overall, these findings reveal the involvement of the indole‐aminergic pathway in rutin's protective influence against EtOH‐induced testicular impairment in rats.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37350278</pmid><doi>10.1111/bcpt.13919</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2826-4844</orcidid></addata></record> |
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| subjects | alcohol Antioxidants Biomarkers Damage prevention Dioxygenase Drinking behavior Drinking water Ethanol Exposure Impairment indoleamine 2,3‐dioxygenase Inflammation Lipid peroxidation Lipids male rats oxidative‐inflammatory stress Peroxidation Perturbation Rutin Testes Tryptophan |
| title | The antioxidant/anti‐inflammatory protective effects of rutin against ethanol‐induced testicular perturbation in rats: Involvement of the immunosuppressive indoleamine 2,3‐dioxygenase |
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