The antioxidant/anti‐inflammatory protective effects of rutin against ethanol‐induced testicular perturbation in rats: Involvement of the immunosuppressive indoleamine 2,3‐dioxygenase

This study investigated the influence of rutin against EtOH‐induced testicular impairment in rats and the involvement of the indole‐aminergic pathway. Four groups of eight rats each were orally exposed to drinking water (Group 1), EtOH (5 g/kg bwt, Group 2), R (5 g/kg bwt, Group 3), and EtOH + R (5 ...

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Veröffentlicht in:	Basic & clinical pharmacology & toxicology 2023-09, Vol.133 (3), p.254-264
Hauptverfasser:	Ebokaiwe, Azubuike Peter, Obasi, Doris Olachi, Osawe, Sharon Oluchi, Njoku, Rex Clovis C.
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohol Antioxidants Biomarkers Damage prevention Dioxygenase Drinking behavior Drinking water Ethanol Exposure Impairment indoleamine 2,3‐dioxygenase Inflammation Lipid peroxidation Lipids male rats oxidative‐inflammatory stress Peroxidation Perturbation Rutin Testes Tryptophan
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Beschreibung
Zusammenfassung:	This study investigated the influence of rutin against EtOH‐induced testicular impairment in rats and the involvement of the indole‐aminergic pathway. Four groups of eight rats each were orally exposed to drinking water (Group 1), EtOH (5 g/kg bwt, Group 2), R (5 g/kg bwt, Group 3), and EtOH + R (5 g/kg bwt + 50 mg/kg bwt, Group 4) via gavage for 15 days. Results showed that exposure to EtOH significantly (p
ISSN:	1742-7835 1742-7843
DOI:	10.1111/bcpt.13919