Age at menopause and all-cause and cause-specific dementia: a prospective analysis of the UK Biobank cohort

Abstract STUDY QUESTION Are there associations between natural or surgical menopause and incident dementia by age at menopause? SUMMARY ANSWER Compared to age at menopause of 46–50 years, earlier natural menopause (≤40 and 41–45 years) was related to higher risk of all-cause dementia, while a U-shap...

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Veröffentlicht in:Human reproduction (Oxford) 2023-09, Vol.38 (9), p.1746-1754
Hauptverfasser: Hao, Wenting, Fu, Chunying, Dong, Caiyun, Zhou, Chunmiao, Sun, Huizi, Xie, Ziwei, Zhu, Dongshan
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Sprache:eng
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Zusammenfassung:Abstract STUDY QUESTION Are there associations between natural or surgical menopause and incident dementia by age at menopause? SUMMARY ANSWER Compared to age at menopause of 46–50 years, earlier natural menopause (≤40 and 41–45 years) was related to higher risk of all-cause dementia, while a U-shape relationship was observed between age at surgical menopause and risk of dementia. WHAT IS KNOWN ALREADY Menopause marks the end of female reproductive period. Age at menopause reflects the length of exposure to endogenous estrogen. Evidence on the association between age at natural, surgical menopause, and risk of dementia has been inconsistent. STUDY DESIGN, SIZE, DURATION A population-based cohort study involving 160 080 women who participated in the UK Biobank study. PARTICIPANTS/MATERIALS, SETTING, METHODS Women with no dementia at baseline, and had no missing data on key exposure variables and covariates were included. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs on the association of categorical menopause age with incident all-cause dementia, Alzheimer’s disease (AD) and vascular dementia (VD). Restricted cubic splines were used to model the non-linear relationship between continuous age at natural, surgical menopause, and risk of dementia. In addition, we analyzed the interaction effect of ever-used menopausal hormone therapy (MHT) at baseline, income level, leisure activities, and age at menopause on risk of dementia. MAIN RESULTS AND THE ROLE OF CHANCE Compared to women with age at menopause of 46–50 years, women with earlier natural menopause younger than 40 years (1.36, 1.01–1.83) and 41–45 years (1.19, 1.03–1.39) had a higher risk of all-cause dementia, while late natural menopause >55 years was linked to lower risk of dementia (0.83, 0.71–0.98). Compared to natural menopause, surgical menopause was associated with 10% higher risk of dementia (1.10, 0.98–1.24). A U-shape relationship was observed between surgical menopause and risk of dementia. Women with surgical menopause before age 40 years (1.94, 1.38–2.73) and after age 55 years (1.65, 1.21–2.24) were both linked to increased risk of all-cause dementia. Women with early natural menopause without ever taking MHT at baseline had an increased risk of AD. Also, in each categorized age at the menopause level, higher income level or higher number of leisure activities was linked to a lowers risk of dementia. LIMITATIONS, REASONS FOR CAUTION Menopausal age was
ISSN:0268-1161
1460-2350
DOI:10.1093/humrep/dead130