Evolution of Antibiotic Resistance in Escherichia coli and Klebsiella pneumoniae from Urine Cultures

Determine the evolution of antibiotic resistance of symptomatic bacteriuria caused by and in Granada. A descriptive retrospective study was carried out, including antibiograms of urine cultures in which microorganisms identified as and , were isolated in the Microbiology laboratory of the Hospital Universitario Virgen de las Nieves (Granada, Spain) between January 2016 and June 2021. was the most frequent isolate (10,048) and its resistance to ampicillin (59.45%) and ticarcillin (59.59%), and the increase to cefepime (15.07%) and amoxicillin-clavulanic acid (17.67%) is noteworthy. (2222) is notable for resistance to Fosfomycin (27.91%) and an increase to ciprofloxacin (37.79%) and amoxicillin-clavulanic acid (36.63%). Resistance is generally higher in hospitalized patients, males, and adults. Antibiotic resistance to the studied is on the rise, requiring empirical treatment targeted to the population area.