The case against secondary epileptogenesis

Secondary epileptogenesis is a theory that hypothesizes that uncontrolled seizures in people with epilepsy lead to the development of new sites of seizure onset. This process has often been cited when people experience a new seizure type after a period of poor seizure control. The theory proposes that repeated seizures induce changes in regions of the brain that are regularly recruited into the seizure. These hypothetical changes can then lead to a new, independent seizure onset zone. The concept is based on a number of clinical observations which secondary epileptogenesis could explain. However there are alternative explanations from the clinic as well as from the laboratory that call the process into question. In this review some of the observations that have been used to support the theory will be reviewed, and the many counterarguments will be presented. At this time there is little evidence to support secondary epileptogenesis and much to refute it. •Recurrent seizures can lead to structural and physiological changes.•These changes are different than the changes that lead to spontaneous seizures.•No evidence that recurrent seizures cause neuronal loss or new seizure types.•People can have multiple seizure types from primary pathologies.•Secondary epileptogenesis is an unlikely cause of new seizure types.