Anticancer evaluation of benzofuran derivatives linked to dipiperazine moiety

[Display omitted] In this work, a series of novel benzofuran derivatives linked to dipiperazine moiety have been prepared, and in vitro anticancer activity against Hela and A549 was investigated. The results demonstrated that benzofuran derivatives exerted potent antitumor effect. Especially, compou...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2023-07, Vol.91, p.129378-129378, Article 129378
Hauptverfasser:	Liu, Yixin, Wu, Zhao, Li, Minxin, Gao, Hui, Wan, Chunping, Mao, Zewei
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer Antineoplastic Agents - pharmacology Apoptosis Benzofuran Benzofurans - pharmacology Cell Line, Tumor Cell Proliferation Dipiperazine Drug Screening Assays, Antitumor HeLa Cells Humans Molecular Structure Structure-Activity Relationship
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Zusammenfassung:	[Display omitted] In this work, a series of novel benzofuran derivatives linked to dipiperazine moiety have been prepared, and in vitro anticancer activity against Hela and A549 was investigated. The results demonstrated that benzofuran derivatives exerted potent antitumor effect. Especially, compounds 8c and 8d showed better antitumor activity against A549 (IC50 = 0.12 μM and 0.43 μM). Further mechanism study indicated that compound 8d could significantly induce cell apoptosis in A549 by FACs analysis.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2023.129378