Cardiovascular Safety of Testosterone-Replacement Therapy

In a randomized trial involving men with hypogonadism and preexisting or a risk of cardiovascular disease, testosterone therapy was noninferior to placebo with respect to major adverse cardiac events.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-07, Vol.389 (2), p.107-117
Hauptverfasser:	Lincoff, A. Michael, Bhasin, Shalender, Flevaris, Panagiotis, Mitchell, Lisa M., Basaria, Shehzad, Boden, William E., Cunningham, Glenn R., Granger, Christopher B., Khera, Mohit, Thompson, Ian M., Wang, Qiuqing, Wolski, Kathy, Davey, Deborah, Kalahasti, Vidyasagar, Khan, Nader, Miller, Michael G., Snabes, Michael C., Chan, Anna, Dubcenco, Elena, Li, Xue, Yi, Tingting, Huang, Bidan, Pencina, Karol M., Travison, Thomas G., Nissen, Steven E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aging Aging General Cardiology Cardiology General Cardiovascular disease Cardiovascular diseases Cardiovascular Diseases - chemically induced Cardiovascular Diseases - epidemiology Cerebral infarction Clinical Medicine Confidence intervals Coronary Disease Design Diabetes Mellitus, Type 2 Double-Blind Method Double-blind studies Drug dosages Embolism Endocrinology Endocrinology General Enrollments FDA approval Gels Geriatrics Heart attacks Heart failure Hormone replacement therapy Hormone Replacement Therapy - adverse effects Hormone Replacement Therapy - methods Humans Hypogonadism Hypogonadism - blood Hypogonadism - drug therapy Laboratories Male Middle age Middle Aged Myocardial Infarction Myocardial Infarction - epidemiology Outpatient-Based Clinical Medicine Placebos Prevention Prostate cancer Prostate Disease Prostate Disease General Safety Sensitivity analysis Statistical analysis Stroke Stroke - epidemiology Testosterone Testosterone - adverse effects Testosterone - blood Testosterone - therapeutic use Transdermal Patch Urology
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Beschreibung
Zusammenfassung:	In a randomized trial involving men with hypogonadism and preexisting or a risk of cardiovascular disease, testosterone therapy was noninferior to placebo with respect to major adverse cardiac events.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2215025