Matching metabolic supply to demand optimizes microbial growth

Matching metabolic supply to demand optimizes microbial growth

Recent research has strengthened the notion that microbes allocate their biosynthetic capacity to maximize the growth rate, λ. Yet many microbes can grow substantially faster after laboratory evolution. Chure and Cremer advance a resource-allocation model, which they derive from first principles, th...

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Veröffentlicht in:Trends in microbiology (Regular ed.) 2023-08, Vol.31 (8), p.769-771
Hauptverfasser: Flamholz, Avi I., Goyal, Akshit
Format: Artikel
Sprache:eng
Schlagworte:
growth laws
metabolic control
physiology
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Zusammenfassung:Recent research has strengthened the notion that microbes allocate their biosynthetic capacity to maximize the growth rate, λ. Yet many microbes can grow substantially faster after laboratory evolution. Chure and Cremer advance a resource-allocation model, which they derive from first principles, that offers resolution to this conundrum.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2023.06.003