Nanoparticles loaded with Daunorubicin as an advanced tool for cancer therapy

Nowadays, with the advent of cutting-edge technologies in the field of biotechnology, some highly advanced medical methods are introduced to treat cancers more efficiently. In the chemotherapy processes, anti-cancer drugs can be encapsulated in a stimuli-responsive coating which is capable of being functionalized by diverse ligands to increase the biocompatibility and control drug release behavior in a targeted drug delivery system. Nanoparticles (NPs) are playing an important role as nanocarriers in chemotherapy procedures, recently, numerous novel drug delivery systems have been studied which employed diverse types of NPs with remarkable structural features like porous nanocarriers with active and extended surface areas to enhance the drug loading and delivery efficacy. In this study, Daunorubicin (DAU) as an effective anti-cancer drug for treating various cancers introduced, and its application for novel drug delivery systems either as a single chemotherapy agent or co-delivery alongside other drugs with diverse NPs has been reviewed. [Display omitted] •Stimuli and non-responsive polymeric Daunorubicin-loaded NPs applied in cancer therapy.•Stimuli and non-responsive liposomal Daunorubicin-loaded NPs applied in cancer therapy.•Carbon and inorganic-based Daunorubicin-loaded NPs applied in cancer therapy.•Co-delivery capability of Daunorubicin with other drugs to treat cancers.