A leading role for interferon as a treatment target in Sjögren syndrome

A leading role for interferon as a treatment target in Sjögren syndrome

No drugs are yet approved for the treatment of primary Sjögren syndrome, despite a large number of clinical trials. Non-conventional approaches can help to identify novel therapeutic targets. Using a drug-repositioning transcriptomic approach, interferon has emerged once again as a major target for...

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Veröffentlicht in:Nature reviews. Rheumatology 2023-08, Vol.19 (8), p.468-469
Hauptverfasser: Verstappen, Gwenny M., Kroese, Frans G. M.
Format: Artikel
Sprache:eng
Schlagworte:
631/250/38
692/4023/1670/122/1810
Cell cycle
Clinical trials
Cytokines
Drug development
Drugs
Exocrine glands
Gene expression
Genetic engineering
Humans
Interferon
Interferons
Kinases
Medicine
Medicine & Public Health
News & Views
news-and-views
Pathogenesis
Rheumatology
Sjogren's Syndrome
Therapeutic targets
Transcriptomics
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Beschreibung
Zusammenfassung:No drugs are yet approved for the treatment of primary Sjögren syndrome, despite a large number of clinical trials. Non-conventional approaches can help to identify novel therapeutic targets. Using a drug-repositioning transcriptomic approach, interferon has emerged once again as a major target for intervention in this disease process.
ISSN:1759-4790
1759-4804
DOI:10.1038/s41584-023-00991-9