Guiding DNA repair at the nuclear periphery

The nuclear envelope participates in the spatial regulation of DNA repair, but the mechanisms behind this are unclear. A study now reports that a nuclear envelope-localized nuclease, NUMEN/ENDOD1, guides the choice of DNA-repair pathway by inhibiting the resection of DNA ends and aberrant recombinat...

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Veröffentlicht in:	Nature cell biology 2023-07, Vol.25 (7), p.928-930
Hauptverfasser:	Audibert, Sylvain, Soutoglou, Evi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/147 631/80/103 Biology Biomedical and Life Sciences Breast cancer Cancer Research Cell Biology Cell cycle Cell Nucleus - genetics Deoxyribonucleic acid Developmental Biology DNA DNA damage DNA Repair Enzymes Genes Genomes Life Sciences Mutation News & Views news-and-views Nuclease Proteins Recombination Stem Cells Tumors Yeast
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