Guiding DNA repair at the nuclear periphery

Guiding DNA repair at the nuclear periphery

The nuclear envelope participates in the spatial regulation of DNA repair, but the mechanisms behind this are unclear. A study now reports that a nuclear envelope-localized nuclease, NUMEN/ENDOD1, guides the choice of DNA-repair pathway by inhibiting the resection of DNA ends and aberrant recombinat...

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Veröffentlicht in:Nature cell biology 2023-07, Vol.25 (7), p.928-930
Hauptverfasser: Audibert, Sylvain, Soutoglou, Evi
Format: Artikel
Sprache:eng
Schlagworte:
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Biology
Biomedical and Life Sciences
Breast cancer
Cancer Research
Cell Biology
Cell cycle
Cell Nucleus - genetics
Deoxyribonucleic acid
Developmental Biology
DNA
DNA damage
DNA Repair
Enzymes
Genes
Genomes
Life Sciences
Mutation
News & Views
news-and-views
Nuclease
Proteins
Recombination
Stem Cells
Tumors
Yeast
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Beschreibung
Zusammenfassung:The nuclear envelope participates in the spatial regulation of DNA repair, but the mechanisms behind this are unclear. A study now reports that a nuclear envelope-localized nuclease, NUMEN/ENDOD1, guides the choice of DNA-repair pathway by inhibiting the resection of DNA ends and aberrant recombination, ensuring genome stability.
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-023-01164-2