ortho -Lithiation driven one-pot synthesis of quinazolines via [2 + 2 + 2] cascade annulation of halofluorobenzenes with nitriles

ortho -Lithiation driven one-pot synthesis of quinazolines via [2 + 2 + 2] cascade annulation of halofluorobenzenes with nitriles

A one-pot synthesis of 2,4-disubstituted quinazoline derivatives from halofluorobenzenes with nitriles was reported, sequential nucleophilic addition and S Ar reaction. The advantages of the present approach are transition metal free, easy to operate, and all the starting materials are commercially...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-06, Vol.21 (25), p.5297-5304
Hauptverfasser: Hsueh, Jen-Chun, Szu, Fu-En, Yu, Yin-Yin, Leung, Man-Kit
Format: Artikel
Sprache:eng
Schlagworte:
Chemical reactions
Cyanide
Nitriles
Synthesis
Transition metals
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Zusammenfassung:A one-pot synthesis of 2,4-disubstituted quinazoline derivatives from halofluorobenzenes with nitriles was reported, sequential nucleophilic addition and S Ar reaction. The advantages of the present approach are transition metal free, easy to operate, and all the starting materials are commercially available.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob00741c