Clinical outcomes of endoscopic submucosal dissection for giant rectal tumors larger than 8 cm: A European referral center experience

To date, western data on colorectal ESD are limited. This study aimed to assess the efficacy and safety of rectal ESD for superficial lesions ≥ 8 cm. A total of 138 superficial rectal neoplasms treated by ESD were allocated in two groups: 25 in the “giant” ESD group and 113 in the control group. En bloc resection was achieved in 96% of cases in both groups. En bloc R0 resection rate was similar between the “giant” ESD group and the control group (84% vs 86%; p: 0.5) and curative resection was higher in the control group (81%) than in “giant” ESD group (68%) without reaching statistical significance (p: 0.2). Dissection time was significantly longer in the “giant” ESD group (251 vs 108 min; p