Carbon nanotubes activate inflammatory signalling through binding to Siglec-14

Carbon nanotubes activate inflammatory signalling through binding to Siglec-14

Discovery of a novel axis through which multi-walled carbon nanotubes (MWCNTs) elicit toxicity in human macrophages, involving the propagation of inflammatory signalling via the Siglec-14-DAP12-Syk pathway, and how it may be controlled pharmacologically.

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Bibliographische Detailangaben
Veröffentlicht in:Nature nanotechnology 2023-06, Vol.18 (6), p.544-545
Hauptverfasser: Greene, Michelle K., Scott, Christopher J.
Format: Artikel
Sprache:eng
Schlagworte:
631/61/350
639/301
Carbon
Chemistry and Materials Science
Cytokines
DAP12 protein
Immunoglobulins
Inflammation
Macrophages
Materials Science
Multi wall carbon nanotubes
Nanotechnology
Nanotechnology and Microengineering
Nanotubes
News & Views
news-and-views
Proteins
Signal transduction
Signaling
Syk protein
Toxicity
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Beschreibung
Zusammenfassung:Discovery of a novel axis through which multi-walled carbon nanotubes (MWCNTs) elicit toxicity in human macrophages, involving the propagation of inflammatory signalling via the Siglec-14-DAP12-Syk pathway, and how it may be controlled pharmacologically.
ISSN:1748-3387
1748-3395
DOI:10.1038/s41565-023-01420-4