The Impact of Sinonasal Symptoms in Relation to Potentially Life‐Threatening Comorbidities

Objective While general health may be influenced by sinonasal symptoms, their effects may be overshadowed by comorbid states which may be more serious. To assess the validity of this postulate, we measured the extent to which sinonasal symptoms and concurrent conditions influenced general health. Study Design Observational outcomes study. Setting Academic medical center, community care sites. Methods Adults with sinonasal symptoms completed the 22‐item Sinonasal Outcome Test, along with the Patient‐Reported Outcomes Measurement Information System global health short form. Comorbidities were categorized with the Deyo modification of the Charlson comorbidity index. Multivariate regression analyses were utilized to determine the relative impact of sinonasal symptoms and concurrent comorbid conditions on general health. Results Data from 219 consecutive patients demonstrated that sinonasal symptoms were associated with significantly diminished general physical (β = −1.431, p