Research progress on the role of PDGF/PDGFR in type 2 diabetes

Platelet-derived growth factors (PDGFs) are basic proteins stored in the α granules of platelets. PDGFs and their receptors (PDGFRs) are widely expressed in platelets, fibroblasts, vascular endothelial cells, platelets, pericytes, smooth muscle cells and tumor cells. The activation of PDGFR plays a number of critical roles in physiological functions and diseases, including normal embryonic development, cellular differentiation, and responses to tissue damage. In recent years, emerging experimental evidence has shown that activation of the PDGF/PDGFR pathway is involved in the development of diabetes and its complications, such as atherosclerosis, diabetic foot ulcers, diabetic nephropathy, and retinopathy. Research on targeting PDGF/PDGFR as a treatment has also made great progress. In this mini-review, we summarized the role of PDGF in diabetes, as well as the research progress on targeted diabetes therapy, which provides a new strategy for the treatment of type 2 diabetes. •PDGF/PDGFR pathway is aberrantly activated in type 2 diabetes.•PDGF promotes insulin resistance and pancreatic β cell proliferation.•PDGF promotes diabetic wound healing.•PDGF promotes atherosclerosis.•PDGF is an important stimulator of proliferative diabetic retinopathy.