Genistein: a promising modulator of apoptosis and survival signaling in cancer

Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and reduced postmenopausal complications owing to its phytoestrogen properties, it has been widely...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Naunyn-Schmiedeberg's archives of pharmacology 2023-11, Vol.396 (11), p.2893-2910
Hauptverfasser: Joshi, Hemant, Gupta, Dhruv Sanjay, Abjani, Nosheen Kamruddin, Kaur, Ginpreet, Mohan, Chakrabhavi Dhananjaya, Kaur, Jagjit, Aggarwal, Diwakar, Rani, Isha, Ramniwas, Seema, Abdulabbas, Hadi Sajid, Gupta, Madhu, Tuli, Hardeep Singh
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Genistein, a commonly occurring isoflavone, has recently gained popularity owing to its ever-expanding spectrum of pharmacological benefits. In addition to health benefits such as improved bone health and reduced postmenopausal complications owing to its phytoestrogen properties, it has been widely evaluated for its anti-cancer potential. Several studies have established the potential for its usage in the management of breast, lung, and prostate cancers, and its usage has significantly evolved from early applications in traditional systems of medicine. This review offers an insight into its current status of usage, the chemistry, and pharmacokinetics of the molecule, an exploration of its apoptotic mechanisms in cancer management, and opportunities for synergism to improve therapeutic outcomes. In addition to this, the authors have presented an overview of recent clinical trials, to offer an understanding of contemporary studies and explore prospects for a greater number of focused trials, moving forward. Advancements in the application of nanotechnology as a strategy to improve safety and efficacy have also been highlighted, with a brief discussion of results from safety and toxicology studies.
ISSN:0028-1298
1432-1912
DOI:10.1007/s00210-023-02550-1