The innate effects of plant secondary metabolites in preclusion of gynecologic cancers: Inflammatory response and therapeutic action

Gynecologic cancers can make up the bulk of cancers in both humans and animals. The stage of diagnosis and the type of tumor, its origin, and its spread are a few of the factors that influence how effectively a treatment modality works. Currently, radiotherapy, chemotherapy, and surgery are the major treatment options recommended for the eradication of malignancies. The use of several anti-carcinogenic drugs increases the chance of harmful side effects, and patients might not react to the treatments as expected. The significance of the relationship between inflammation and cancer has been underscored by recent research. As a result, it has been shown that a variety of phytochemicals with beneficial bioactive effects on inflammatory pathways have the potential to act as anti-carcinogenic medications for the treatment of gynecologic cancer. The current paper reviews the significance of inflammatory pathways in gynecologic malignancies and discusses the role of plants-derived secondary metabolites that are useful in the treatment of cancer. •The salient features of this review article with potential clinical relevance include:•Plants' secondary metabolites are typically excellent sources of therapeutic development leads, particularly for the treatment of gynecological tumors.•Plants' metabolites are excellent sources of therapeutic development that leads to the treatment of gynecological tumors.•Epidemiological studies show that eating a diet rich in antioxidant-rich fruits and vegetables reduces the risk of developing a number of oxidative diseases, including diabetes, cancer, and cardiovascular disease.•Antioxidant-rich fruits and vegetables reduce the risk of oxidative diseases: diabetes, cancer, and cardiovascular disease.