Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels

Insights into stoichiometry and gating of heteromeric LRRC8A–LRRC8C volume-regulated anion channels

Volume-regulated anion channels (VRACs) are critical for cell volume regulation, neuron–glia interaction, metabolism, and immunity. They are formed as heteromers of LRRC8 proteins with unknown stoichiometry. Two papers now reveal the structures of heteromeric LRRC8A and LRRC8C channels, providing in...

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Veröffentlicht in:Nature structural & molecular biology 2023-06, Vol.30 (6), p.714-716
Hauptverfasser: Hagino, Tatsuya, Qiu, Zhaozhu
Format: Artikel
Sprache:eng
Schlagworte:
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Amino acids
Anion channels
Anions
Biochemistry
Biological Microscopy
Biomedical and Life Sciences
Cell size
Channel gating
Ion channels
Life Sciences
Lipids
Membrane Biology
Membrane Proteins
Molecular biology
Neuronal-glial interactions
News & Views
news-and-views
Permeability
Protein Structure
Proteins
Stoichiometry
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Zusammenfassung:Volume-regulated anion channels (VRACs) are critical for cell volume regulation, neuron–glia interaction, metabolism, and immunity. They are formed as heteromers of LRRC8 proteins with unknown stoichiometry. Two papers now reveal the structures of heteromeric LRRC8A and LRRC8C channels, providing insights into channel assembly and gating.
ISSN:1545-9993
1545-9985
DOI:10.1038/s41594-023-01012-9