Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection/quantification and vaccination strategies

Specific HBsAg mutations are known to hamper HBsAg recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape mutations from 2005 to 2019 and t...

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Veröffentlicht in:Emerging microbes & infections 2023-12, Vol.12 (1), p.2219347-2219347
Hauptverfasser: Piermatteo, Lorenzo, D'Anna, Stefano, Bertoli, Ada, Bellocchi, Maria, Carioti, Luca, Fabeni, Lavinia, Alkhatib, Mohammad, Frazia, Simone La, Lichtner, Miriam, Mastroianni, Claudio, Sanctis, Giuseppe De, Marignani, Massimo, Pasquazzi, Caterina, Iapadre, Nerio, Parruti, Giustino, Cappiello, Giuseppina, Vecchiet, Jacopo, Malagnino, Vincenzo, Grelli, Sandro, Ceccherini-Silbertein, Francesca, Andreoni, Massimo, Sarmati, Loredana, Svicher, Valentina, Salpini, Romina
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Sprache:eng
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Zusammenfassung:Specific HBsAg mutations are known to hamper HBsAg recognition by neutralizing antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their impact and spreading over time is limited. Here, we characterize the circulation of vaccine-escape mutations from 2005 to 2019 and their correlation with virological parameters in a large cohort of patients infected with HBV genotype-D (N = 947), dominant in Europe. Overall, 17.7% of patients harbours ≥1 vaccine-escape mutation with the highest prevalence in subgenotype-D3. Notably, complex profiles (characterized by ≥2 vaccine-escape mutations) are revealed in 3.1% of patients with a prevalence rising from 0.4% in 2005-2009 to 3.0% in 2010-2014 and 5.1% in 2015-2019 (P = 0.007) (OR[95%CI]:11.04[1.42-85.58], P = 0.02, by multivariable-analysis). The presence of complex profiles correlates with lower HBsAg-levels (median[IQR]:40[0-2905]IU/mL for complex profiles vs 2078[115-6037]IU/ml and 1881[410-7622]IU/mL for single or no vaccine-escape mutation [P 
ISSN:2222-1751
2222-1751
DOI:10.1080/22221751.2023.2219347