Moving beyond nanotechnology to uncover a glimmer of hope in diabetes medicine: Effective nanoparticle‐based therapeutic strategies for the management and treatment of diabetic foot ulcers

Hyperglycemia, a distinguishing feature of diabetes mellitus that might cause a diabetic foot ulcer (DFU), is an endocrine disorder that affects an extremely high percentage of people. Having a comprehensive understanding of the molecular mechanisms underlying the pathophysiology of diabetic wound healing can help researchers and developers design effective therapeutic strategies to treat the wound healing process in diabetes patients. Using nanoscaffolds and nanotherapeutics with dimensions ranging from 1 to 100 nm represents a state‐of‐the‐art and viable therapeutic strategy for accelerating the wound healing process in diabetic patients, particularly those with DFU. Nanoparticles can interact with biological constituents and infiltrate wound sites owing to their reduced diameter and enhanced surface area. Furthermore, it is noteworthy that they promote the processes of vascularization, cellular proliferation, cell signaling, cell‐to‐cell interactions, and the formation of biomolecules that are essential for effective wound healing. Nanomaterials possess the ability to effectively transport and deliver various pharmacological agents, such as nucleic acids, growth factors, antioxidants, and antibiotics, to specific tissues, where they can be continuously released and affect the wound healing process in DFU. The present article elucidates the ongoing endeavors in the field of nanoparticle‐mediated therapies for the management of DFU. Significance statement To sum up, this study emphasizes that it may be feasible to develop better treatments for improperly healed diabetic wounds by studying the molecular mechanics of diabetic wound healing. As new products, nanomaterials can transfer nucleic acids, growth factors, antioxidants, and antibiotics to specified tissues for continuous release. Moreover, nanomaterials are more likely to interact with biological systems and infiltrate wound sites due to their smaller diameter and larger surface area. Hence, nano‐scaffolds and nano‐therapeutics can accelerate diabetic wound healing.