Gap junctions regulate the development of neural circuits in the neocortex

Gap junctions between cells are ubiquitously expressed in the developing brain. They are involved in major steps of neocortical development, including neurogenesis, cell migration, synaptogenesis, and neural circuit formation, and have been implicated in cortical column formation. Dysfunctional gap junctions can contribute to or even cause a variety of brain diseases. Although the role of gap junctions in neocortical development is better known, a comprehensive understanding of their functions is far from complete. Here we explore several critical open questions surrounding gap junctions and their involvement in neural circuit development. Addressing them will greatly impact our understanding of the fundamental mechanisms of neocortical structure and function as well as the etiology of brain disease. •Gap junctions regulate cortical neurogenesis and cell migration.•Transient electrical couplings play an important role in chemical synapse formation.•Gap junctions contribute to cortical column formation.•Dysfunctional gap junctions contribute to CNS pathologies.