Pepsin Increases the Proliferation of Vocal Cord Leukoplakia Epithelial Cells by Inducing Autophagy

To investigate the role of H /K ATPase in the proliferation of pepsin-induced vocal cord leukoplakia (VCL) cells. Translation research. Affiliated Hospital of University. Immunohistochemistry was used to detect pepsin, H /K ATPase (ATP4A and ATP4B subunits) in VCL cells with varying degrees of dysplasia. After primary cultures of VCL cells had been established, the effects of acidified pepsin on the proliferation, autophagy, and H /K -ATPase distribution of VCL cells were investigated. The levels of pepsin, ATP4A, and ATP4B were significantly higher in VCL tissue with moderate-to-severe dysplasia than in normal tissue (p