Rhythmic cilia changes support SCN neuron coherence in circadian clock

The suprachiasmatic nucleus (SCN) drives circadian clock coherence through intercellular coupling, which is resistant to environmental perturbations. We report that primary cilia are required for intercellular coupling among SCN neurons to maintain the robustness of the internal clock in mice. Cilia...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2023-06, Vol.380 (6648), p.972-979
Hauptverfasser:	Tu, Hai-Qing, Li, Sen, Xu, Yu-Ling, Zhang, Yu-Cheng, Li, Pei-Yao, Liang, Li-Yun, Song, Guang-Ping, Jian, Xiao-Xiao, Wu, Min, Song, Zeng-Qing, Li, Ting-Ting, Hu, Huai-Bin, Yuan, Jin-Feng, Shen, Xiao-Lin, Li, Jia-Ning, Han, Qiu-Ying, Wang, Kai, Zhang, Tao, Zhou, Tao, Li, Ai-Ling, Zhang, Xue-Min, Li, Hui-Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological clocks Cilia Cilia - metabolism Cilia - physiology Circadian Clocks - genetics Circadian Rhythm - physiology Circadian rhythms Gene expression Gene Expression Regulation Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Jet lag Mice Mice, Transgenic Neurons Signal Transduction Signaling Suprachiasmatic nucleus Suprachiasmatic Nucleus Neurons - physiology
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