Defect-Rich CoFe-Layered Double Hydroxides as Superior Peroxidase-like Nanozymes for the Detection of Ascorbic Acid

The development of artificial enzymes with superior catalytic properties to natural enzymes has been a long-standing goal of chemists. Herein, defect-rich CoFe-layered double hydroxides (d-CoFe-LDHs) nanosheets are developed and used as superior peroxidase-like nanozymes for the detection of ascorbi...

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Veröffentlicht in:ACS applied materials & interfaces 2023-06, Vol.15 (22), p.26263-26272
Hauptverfasser: Ning, Yiping, Sun, Yi, Yang, Xiang, Li, Yaping, Han, Aijuan, Wang, Bingqing, Liu, Junfeng
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Sprache:eng
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Zusammenfassung:The development of artificial enzymes with superior catalytic properties to natural enzymes has been a long-standing goal of chemists. Herein, defect-rich CoFe-layered double hydroxides (d-CoFe-LDHs) nanosheets are developed and used as superior peroxidase-like nanozymes for the detection of ascorbic acid (AA). The d-CoFe-LDHs with an average thickness of ∼3 nm and a lateral size of ∼20 nm are synthesized through rapid nucleation in a colloid mill, which exhibited abundant unsaturated sites (oxygen vacancies and cobalt vacancies). Impressively, d-CoFe-LDHs exhibited excellent peroxidase-mimicking performance with strong substrate affinity and robustness in a wide pH range. Density functional theory calculations show that d-CoFe-LDHs have lower H2O2 adsorption energy, which promotes the decomposition of H2O2, thereby improving the catalytic activity. The chromogenic system of d-CoFe-LDHs and 3,3′,5,5′-tetramethylbenzidine can be used to accurately detect the content of AA, and the detection limit is about 3.6 μM. This study opens up a new approach for the construction of highly active defective LDH peroxidases for the detection of biomolecules.
ISSN:1944-8244
1944-8252
1944-8252
DOI:10.1021/acsami.3c01412