Effects of zinc supplementation in mitigating the harmful effects of chronic cadmium exposure in a zebrafish model

Cadmium (Cd) is a heavy metal that is highly toxic to living organisms, including humans. But the dietary zinc (Zn) supplements play critical role in minimizing or preventing Cd poisoning, without any side effects. The underlying mechanisms, however, have not been thoroughly investigated. Therefore, in this study, we investigated the use of Zn as a protection against Cd toxicity in zebrafish models. The obtained results confirmed the levels of antioxidant enzymes and supported the synergistic effects of Zn in reducing Cd toxicity. The lipid, carbohydrate, and protein concentrations in the liver tissue have also been negatively impacted by Cd; however, treatment with Zn has lessened these adverse effects. Furthermore, the level of 8-hydroxy-2′ –deoxyguanosine (8-OHdG), caspase-3 also confirms the protective effects of Zn in reducing DNA damage caused by Cd. The results of this study demonstrate that a Zn supplement can lessen the harmful effects of Cd in zebrafish model. [Display omitted] •Protective role of Zinc (Zn) has investigated against Cd-induced DNA damage.•DNA damage was studied using caspase-3 and 8-OHdG levels in zebrafish liver tissues.•ROS scavenging activity of Zn was investigated against Cd-treated liver tissues.