Investigation of the clinical efficacy of CGF and ozone in the management of alveolar osteitis: a randomized controlled trial

Objectives To investigate the efficacy of concentrated growth factors (CGF) and ozone in the treatment of alveolar osteitis (AO). Materials and methods Patients admitted for the treatment of AO and eligible for the study were included and divided into control, ozone, and CGF + ozone groups. For the treatment of AO alveogyl, ozone, and CGF + ozone were applied to control, ozone, and CGF + ozone groups, respectively, and repeated on 3rd day. Demographic data and oral hygiene were recorded at the initial visit. Pain with visual analog scale (VAS) and analgesic consumption were evaluated at the 6th and 24th h, and on 2nd–7th days. Granulation tissue health and inflammation severity were evaluated on the 1st, 3rd, and 7th days. Quality of life was evaluated with the postoperative symptom severity scale (Posse) on the 7th day. Results A total of 60 patients (43 females/17 males; mean age 42.7 ± 13.76 years), 20 patients per group were included. Among the groups, pain scores on the 7th day ( p = 0.042), granulation tissue health on the 3rd ( p = 0.003) and 7th ( p = 0.015) days showed a significant difference while analgesic consumption, Posse scores, and inflammation severity showed no significant differences ( p > 0.05). Between genders analgesic consumption at 6 h ( p = 0.027), 24 h ( p = 0.033), and on the 2nd day ( p = 0.034) and inflammation severity on the 7th day ( p = 0.012) showed significant differences while Posse scores and granulation tissue health showed no significant differences ( p > 0.05). Conclusions This study demonstrates that regenerative treatment which modulates angiogenesis, and tissue regeneration by stimulating stem cells, growth factors, and cytokines with CGF + ozone are more effective than conventional treatment regarding AO. Clinical relevance Usage of CGF and ozone together provides faster and more satisfactory management of AO.