Implementing Logic Gates by DNA Crystal Engineering

DNA self‐assembly computation is attractive for its potential to perform massively parallel information processing at the molecular level while at the same time maintaining its natural biocompatibility. It has been extensively studied at the individual molecule level, but not as much as ensembles in...

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Veröffentlicht in:Advanced materials (Weinheim) 2023-08, Vol.35 (33), p.e2302345-n/a
Hauptverfasser: Zhang, Cuizheng, Paluzzi, Victoria E., Sha, Ruojie, Jonoska, Natasha, Mao, Chengde
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Sprache:eng
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Zusammenfassung:DNA self‐assembly computation is attractive for its potential to perform massively parallel information processing at the molecular level while at the same time maintaining its natural biocompatibility. It has been extensively studied at the individual molecule level, but not as much as ensembles in 3D. Here, the feasibility of implementing logic gates, the basic computation operations, in large ensembles: macroscopic, engineered 3D DNA crystals is demonstrated. The building blocks are the recently developed DNA double crossover‐like (DXL) motifs. They can associate with each other via sticky‐end cohesion. Common logic gates are realized by encoding the inputs within the sticky ends of the motifs. The outputs are demonstrated through the formation of macroscopic crystals that can be easily observed. This study points to a new direction of construction of complex 3D crystal architectures and DNA‐based biosensors with easy readouts. Multiple logic gates are constructed via engineered DNA crystals. Their outputs are crystal formation; thus, can be easily observed. In addition to providing a useful biosensing platform, this work, more importantly, points to the potential of using algorithmic self‐assembly as a way to assemble otherwise non‐accessible, complicated crystal architectures.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.202302345