Widefield oct-angiography-based classification of sickle cell retinopathy

Purpose To assess the capillary non-perfusion in different concentric sectors on widefield optical coherence tomography angiography (WF-OCTA) and to correlate the ratio of non-perfusion (RNP) to the severity of sickle cell retinopathy (SCR). Methods This retrospective, cross-sectional study included eyes of patients with various sickle cell disease (SCD) genotypes having undergone WF-OCTA and ultra-widefield color fundus photography (UWF-CFP). Eyes were grouped as no SCR, non-proliferative SCR or proliferative SCR. RNP was assessed on WF-OCTA montage in different field-of-view (FOV) sectors centered on the fovea: 0–10-degrees circle excluding the foveal avascular zone, the 10–30-degrees circle excluding the optic nerve, the 30–60-degrees circle, and the full 60-degrees circle. Results Forty-two eyes of twenty-eight patients were included. Within each SCR group, mean RNP of the FOV 30–60 sector was higher than all other sectors ( p 18.09, AUC = 0.73, 95% CI 0.53 to 0.93, p = 0.041). To discern no SCR versus proliferative SCR, all sectors had optimal sensitivity and specificity ( p