ILC2s control obesity by regulating energy homeostasis and browning of white fat

[Display omitted] •ILC2s promote browning of adipose tissue through activating M2 macrophages.•ILC2s produced BMP7 affects brown adipogenesis.•ILC2s drive the activation of PPARγ and promote the browning of white fat.•ILC2s secrete MetEnk to activate the PKA pathway to promote browning of white fat. Innate lymphoid cells (ILCs) have been a hot topic in recent research, they are widely distributed in vivo and play an important role in different tissues. The important role of group 2 innate lymphoid cells (ILC2s) in the conversion of white fat into beige fat has attracted widespread attention. Studies have shown that ILC2s regulate adipocyte differentiation and lipid metabolism. This article reviews the types and functions of ILCs, focusing on the relationship between differentiation, development and function of ILC2s, and elaborates on the relationship between peripheral ILC2s and browning of white fat and body energy homeostasis. This has important implications for the future treatment of obesity and related metabolic diseases.