Transmembrane protein 147, as a potential Sorafenib target, could expedite cell cycle process and confer adverse prognosis in hepatocellular carcinoma

Transmembrane protein 147, as a potential Sorafenib target, could expedite cell cycle process and confer adverse prognosis in hepatocellular carcinoma

TMEM147 was identified as a core component of ribosome‐bound translocon complex at ER/NE. So far, sparse studies reported its expression profiling and oncological implications in hepatocellular carcinoma (HCC) patients. Here we inspected TMEM147 expression levels in HCC cohorts from public databases...

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Veröffentlicht in:Molecular carcinogenesis 2023-09, Vol.62 (9), p.1295-1311
Hauptverfasser: Ma, Wanshan, Zhang, Xiaoyu, Lu, Jing, Lv, Shiyu, Zhang, Zhenyu, Ma, Hongxin, Chen, Qianqian, Cao, Wenjing, Zhang, Xiaoning
Format: Artikel
Sprache:eng
Schlagworte:
Bioinformatics
bioinformatics analysis
Cell cycle
Cell proliferation
Clinical outcomes
Ferroptosis
Gene clusters
Hepatocellular carcinoma
Hepatoma
Liver cancer
MAP kinase
Medical prognosis
prognosis
Risk factors
S phase
transmembrane protein 147
Transmembrane proteins
Tumors
Wnt protein
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Zusammenfassung:TMEM147 was identified as a core component of ribosome‐bound translocon complex at ER/NE. So far, sparse studies reported its expression profiling and oncological implications in hepatocellular carcinoma (HCC) patients. Here we inspected TMEM147 expression levels in HCC cohorts from public databases and tumor tissues. TMEM147 was augmented at transcriptional levels (p 
ISSN:0899-1987
1098-2744
DOI:10.1002/mc.23564