Analysis of the effect of urine on the in vitro activity of gepotidacin and levofloxacin against Escherichia coli, Staphylococcus epidermidis, and Staphylococcus saprophyticus

Analysis of the effect of urine on the in vitro activity of gepotidacin and levofloxacin against Escherichia coli, Staphylococcus epidermidis, and Staphylococcus saprophyticus

Gepotidacin is a novel agent in development for treatment of gonorrhea and uncomplicated urinary tract infection. This study determined the effect of urine on the in vitro activity of gepotidacin and levofloxacin against relevant bacteria. Study strains were tested by Clinical and Laboratory Standar...

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Veröffentlicht in:Diagnostic microbiology and infectious disease 2023-07, Vol.106 (3), p.115946-115946, Article 115946
Hauptverfasser: Koeth, Laura M., DiFranco-Fisher, Jeanna M., Scangarella-Oman, Nicole E.
Format: Artikel
Sprache:eng
Schlagworte:
Anti-Bacterial Agents - pharmacology
Antimicrobial susceptibility testing
Escherichia coli
Gepotidacin
Humans
Levofloxacin
Levofloxacin - pharmacology
MIC
Microbial Sensitivity Tests
Staphylococcus epidermidis
Staphylococcus saprophyticus
Urine
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Zusammenfassung:Gepotidacin is a novel agent in development for treatment of gonorrhea and uncomplicated urinary tract infection. This study determined the effect of urine on the in vitro activity of gepotidacin and levofloxacin against relevant bacteria. Study strains were tested by Clinical and Laboratory Standards Institute broth microdilution and with method variations: CAMHB with 25%, 50%, 100% urine and pH adjusted 100% urine. Mean dilution difference (DD) of urine minimum inhibitory concentration (MICs) were
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2023.115946