Cycle threshold predicted mortality in a cohort of patients with hematologic malignancies infected with SARS-CoV-2

Cycle threshold predicted mortality in a cohort of patients with hematologic malignancies infected with SARS-CoV-2

•We aimed to determine if SARS-COV-2 cycle threshold could predict mortality.•We included 35 patients with hematologic malignancies with COVID-19.•Cycle threshold was lower in the patients who died compared with the survivors.•SARS-COV-2 cycle threshold predicted mortality in this population. When a...

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Veröffentlicht in:Revista argentina de microbiología 2023-07, Vol.55 (3), p.246-250
Hauptverfasser: Santarelli, Ignacio Martín, Manzella, Diego Jorge, Gallo Vaulet, María Lucía, Rodríguez Fermepín, Marcelo, Crespo, Yanina, Toledo Monaca, Santiago, Dobarro, Martín, Fernández, Sofía Isabel
Format: Artikel
Sprache:eng
Schlagworte:
Argentina
COVID-19
COVID-19 infection
Cycle threshold
Hematologic neoplasms
mortality
myeloma
Neoplasias hematológicas
nose
Polymerase chain reaction
Reacción en cadena de la polimerasa
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Umbral de ciclado
viral load
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Zusammenfassung:•We aimed to determine if SARS-COV-2 cycle threshold could predict mortality.•We included 35 patients with hematologic malignancies with COVID-19.•Cycle threshold was lower in the patients who died compared with the survivors.•SARS-COV-2 cycle threshold predicted mortality in this population. When a SARS-CoV-2 RT-qPCR test is performed, it may determine an indirect measure of viral load called cycle threshold (Ct). Respiratory samples with Ct
ISSN:0325-7541
DOI:10.1016/j.ram.2023.03.002