Metal-Catalyst-Controlled Divergent Synthesis of γ‑Butyrolactones via Intramolecular Coupling of Epoxides with Alcohols

Metal-Catalyst-Controlled Divergent Synthesis of γ‑Butyrolactones via Intramolecular Coupling of Epoxides with Alcohols

A metal-controlled divergent protocol for the synthesis of α- and β-substituted γ-butyrolactones was developed through intramolecular coupling of epoxides with alcohols. This method provides an efficient and practicable way to afford γ-butyrolactones with good efficiency, excellent regioselectivity,...

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Veröffentlicht in:Organic letters 2023-05, Vol.25 (20), p.3618-3622
Hauptverfasser: Liu, Feipeng, Cheng, Zifan, Fang, Yiyun, Wang, Xuchao, Zhao, Lingzi, Rong, Zi-Qiang
Format: Artikel
Sprache:eng
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Zusammenfassung:A metal-controlled divergent protocol for the synthesis of α- and β-substituted γ-butyrolactones was developed through intramolecular coupling of epoxides with alcohols. This method provides an efficient and practicable way to afford γ-butyrolactones with good efficiency, excellent regioselectivity, and broad substrate scope.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00898