ETS2 alleviates acute‐on‐chronic liver failure by suppressing excessive inflammation

Hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is a syndrome with high short‐term mortality. The mechanism of the transcription factor ETS2 in ACLF remains unclear. This study aimed to clarify the molecular basis of ETS2 in ACLF pathogenesis. Peripheral blood mononuclear cells f...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of medical virology 2023-04, Vol.95 (4), p.e28710-n/a
Hauptverfasser:	He, Lulu, Cai, Qun, Liang, Xi, Xin, Jiaojiao, Shi, Dongyan, Ren, Keke, Li, Yun, Chen, Jiaxian, Sun, Suwan, Guo, Beibei, Yang, Hui, Li, Bingqi, Ma, Shiwen, Luo, Jinjin, Hu, Meiqian, Li, Jiaqi, Hu, Wen, Li, Peng, Yao, Heng, Li, Jun, Chen, Xin, Jiang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute-On-Chronic Liver Failure - pathology acute‐on‐chronic liver failure Animals Biomarkers Ets-2 protein ETS2 Failure Gene sequencing Hepatitis B Hepatitis B virus Hepatitis B, Chronic HMGB1 HMGB1 protein HMGB1 Protein - metabolism Humans Immune response Inflammation Inflammation - metabolism Inflammatory response Innate immunity Interleukin 6 Interleukin-6 - genetics Leukocytes (mononuclear) Leukocytes (neutrophilic) Leukocytes, Mononuclear - metabolism Lipopolysaccharides Liver Liver failure Macrophages Mice Mice, Knockout Monocytes Mortality Pathogenesis Peripheral blood mononuclear cells Prognosis Therapeutic targets Transcriptomes Virology Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Hepatitis B virus‐related acute‐on‐chronic liver failure (HBV‐ACLF) is a syndrome with high short‐term mortality. The mechanism of the transcription factor ETS2 in ACLF remains unclear. This study aimed to clarify the molecular basis of ETS2 in ACLF pathogenesis. Peripheral blood mononuclear cells from patients with HBV‐ACLF (n = 50) were subjected to RNA sequencing. Transcriptome analysis showed that ETS2 expression was significantly higher in ACLF patients than in patients with chronic liver diseases and healthy subjects (all p
ISSN:	0146-6615 1096-9071
DOI:	10.1002/jmv.28710