Cost-Effectiveness of Recombinant Zoster Vaccine for Adults Aged ≥50 Years in China

Adjuvanted recombinant zoster vaccine (RZV) was the first vaccine made available for herpes zoster in China. Authors aimed to evaluate its economic and health impacts on Chinese adults aged ≥50 years. A lifetime Markov model was developed to compare the cost-effectiveness of RZV with that of no vaccination from a societal perspective. Model inputs were derived from published literature and analyzed in 2022. Outcomes included total costs, quality-adjusted life-years, incremental cost-effectiveness ratio, and number of herpes zoster and herpes zoster−related cases. Sensitivity analyses were performed to examine the robustness of the model results. RZV was more costly than no vaccination by $2.78 billion with an additional 65,008 quality-adjusted life-years gained and could avoid 1,893,530 herpes zoster cases, 295,761 postherpetic neuralgia cases, 51,734 other complications, and 229 herpes zoster−related deaths. Incremental cost-effectiveness ratios of RZV varied in a range of $34,465.5–$51,002.7 per quality-adjusted life-year. RZV for the entire cohort would be cost-effective when discount rate was