Bioconcentration of pharmaceuticals in benthic marine organisms (Holothuria tubulosa, Anemonia sulcata and Actinia equina) exposed to environmental contamination by atenolol and carbamazepine

The present work assess the bioconcentration kinetics of atenolol (ATN) and carbamazepine (CBZ) in common marine organisms including Holothuria tubulosa, Anemonia sulcata and Actinia equina under controlled laboratory conditions. CBZ exhibited higher uptake and excretion rates resulting higher bioconcentration factor (BCF) (41–537 L/kg for CBZ vs 7–50 L/kg for ATN) although both are below the limits established by the European Union (EU). The measured BCF using kinetic data showed some differences with those predicted using the concentrations measured at the steady-state, probably explained because the steady state was not ready reached. The animal-specific BCF followed the order of Holothuria tubulosa >Actinia equina >Anemonia sulcata for ATN while was the opposite for CBZ. The study highlighted between-tissues differences in the digestive tract and the body wall of the Holothuria tubulosa. The work presented is the first to model bioconcentration of ATN and CBZ in holothurian and anemone animal models. [Display omitted] •Bioconcentration of ATN and CBZ in sea cucumber and anemone were investigated.•The tissue distribution of in H. tubulosa was influenced by the physico-chemical properties of compounds.•CBZ exhibited the highest first-order uptake (k1) and elimination rate (k2) constants.•ATN and CBZ could be classified as non bioaccumulative in tested animals.•Differences between predicted and calculated BCF values are found.