SnapShot: Eukaryotic ribosome biogenesis I

Ribosome production is vital for every cell, and failure causes human diseases. It is driven by ∼200 assembly factors functioning along an ordered pathway from the nucleolus to the cytoplasm. Structural snapshots of biogenesis intermediates from the earliest 90S pre-ribosomes to mature 40S subunits...

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Veröffentlicht in:	Cell 2023-05, Vol.186 (10), p.2282-2282.e1
Hauptverfasser:	Hurt, Ed, Cheng, Jingdong, Baβler, Jochen, Iwasa, Janet, Beckmann, Roland
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Nucleolus - metabolism Eukaryotic Cells - metabolism Humans Ribosomal Proteins - metabolism Ribosome Subunits, Small, Eukaryotic - chemistry Ribosome Subunits, Small, Eukaryotic - metabolism Ribosomes - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Ribosome production is vital for every cell, and failure causes human diseases. It is driven by ∼200 assembly factors functioning along an ordered pathway from the nucleolus to the cytoplasm. Structural snapshots of biogenesis intermediates from the earliest 90S pre-ribosomes to mature 40S subunits unravel the mechanisms of small ribosome synthesis. To view this SnapShot, open or download the PDF. Ribosome production is vital for every cell, and failure causes human diseases. It is driven by ∼200 assembly factors functioning along an ordered pathway from the nucleolus to the cytoplasm. Structural snapshots of biogenesis intermediates from the earliest 90S pre-ribosomes to mature 40S subunits unravel the mechanisms of small ribosome synthesis. To view this SnapShot, open or download the PDF.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2023.04.030