Genetic predisposition to subjective well-being, depression, and suicide in relation to COVID-19 susceptibility and severity

Epidemiological studies have reported associations between subjective well-being (SWB), depression, and suicide with COVID-19 illness, but the causality has not been established. We performed a two-sample Mendelian randomization (MR) analysis to investigate the causal link between SWB, depression, suicide and COVID-19 susceptibility and severity. Summary statistics for SWB (298,420 cases), depression (113,769 cases) and suicide (52,208 cases) were obtained from three large-scale GWAS. Data on the associations between the Single Nucleotide Polymorphisms (SNPs) and COVID-19 (159,840 cases), hospitalized COVID-19 (44,986 cases), and severe COVID-19 (18,152 cases) were collected from the COVID-19 host genetics initiative. The causal estimate was calculated by the Inverse Variance Weighted, MR Egger and Weighted Median methods. Sensitivity tests were used to evaluate the validity of the causal relationship. Our results showed that genetically predicted SWB (OR = 0.98, 95 % CI: 0.86–1.10, P = 0.69), depression (OR = 0.76, 95 % CI: 0.54–1.06, P = 0.11), and suicide (OR = 0.99, 95 % CI: 0.96–1.02, P = 0.56) were not causally related to COVID-19 susceptibility. Similarly, we did not find a potential causal relationship between SWB, depression, suicide and COVID-19 severity. This indicated that positive or negative emotions would not make COVID-19 better or worse, and strategies that attempted to use positive emotions to improve COVID-19 symptoms may be useless. Improving knowledge about the SARS-CoV-2 and timely medical intervention to reduce panic during a pandemic is one of the effective measures to deal with the current decrease in well-being and increase in depression and suicide rates. •Positive mood and life satisfaction may not reduce people’s susceptibility to COVID-19 or improve the severity of COVID-19.•Depressed or suicidal individuals were not more susceptible to SARS-CoV-2 or becoming severe.•It is essential to raise awareness of SARS-CoV-2 and to provide timely medical intervention to reduce panic.