Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies

In recent years, brain diseases have seriously threatened human health due to their high morbidity and mortality. Achieving efficient drug delivery to provide satisfactory therapeutic outcomes is currently the greatest challenge in treating brain diseases. The main challenges are the structural peculiarities of the brain and the inability to transport drugs across the blood–brain barrier. Biomimetic nanodelivery systems (BNDSs) applied to the brain have been extensively developed in the preclinical phase to surmount these challenges. Considering the inherent properties of BNDSs, the substantially enhanced ability of BNDS to carry therapeutic agents and their higher selectivity toward lesions offer new opportunities for developing safe and effective therapies. This review summarizes brain-targeting nanotherapies, particularly advanced therapies with biomimetic nano-assistance. Prospects for developing BNDSs and the challenges of their clinical translation are discussed. Understanding and implementing biomimetic nanotherapies may facilitate the development of new targeted strategies for brain disorders. Using different bionanomaterials to treat brain disorders. Use of different bionanomaterials for the treatment of brain diseases, e.g., cell membranes, exosomes, viral vectors, and receptor-mediated biomimetic approaches [Display omitted] •Advanced biomimetic nano-delivery systems for the treatment of brain diseases have been illustrated.•Highlighted pathological mechanisms of BBB in different brain diseases and biomimetic strategies to cope with it.•The perspectives and challenges for accelerating the clinical translation of biomimetic nano-delivery systems are highlighted.