Antibody response elicited by the SARS‐CoV‐2 vaccine booster in patients with multiple sclerosis: Who gains from it?

Background and purpose Although two doses of COVID‐19 vaccine elicited a protective humoral response in most persons with multiple sclerosis (pwMS), a significant group of them treated with immunosuppressive disease‐modifying therapies (DMTs) showed less efficient responses. Methods This prospective...

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Veröffentlicht in:	European journal of neurology 2023-08, Vol.30 (8), p.2357-2364
Hauptverfasser:	Schiavetti, Irene, Inglese, Matilde, Frau, Jessica, Signoriello, Elisabetta, Caleri, Francesca, Stromillo, Maria Laura, Ferrò, Maria Teresa, Rilla, Maria Teresa, Gandoglia, Ilaria, Gazzola, Paola, Brichetto, Giampaolo, Pasquali, Livia, Grimaldi, Luigi, Ulivelli, Monica, Marinelli, Fabiana, Cordera, Susanna, Clerico, Marinella, Conte, Antonella, Salvetti, Marco, Battaglia, Mario Alberto, Franciotta, Diego, Uccelli, Antonio, Sormani, Maria Pia, Maglione, Alessandro, Di Sapio, Alessia, Laroni, Alice, Iovino, Aniello, Mannironi, Antonio, Nucciarone, Barbara, Serrati, Carlo, Nicoletti, Carolina Gabri, Lapucci, Caterina, Mancinelli, Chiara Rosa, Cordioli, Cinzia, Bezzini, Daiana, Carmagnini, Daniele, Brogi, Davide, Nicola, De Stefano, Landi, Doriana, Nobile Orazio, Eduardo, Cocco, Eleonora, Nako, Enri, Assandri, Ester, Baldi, Federica, Siciliano, Gabriele, Cola, Gaia, Perego, Germana, Lus, Giacomo, Bellucci, Gianmarco, Da Rin, Giorgio, Marfia, Girolama Alessandra, Vazzoler, Giulia, Liberatore, Giuseppe, Trivelli, Giuseppe, Callari, Graziella, Petrucci, Loredana, Lorefice, Lorena, Ruggiero, Lucia, Monti Bragadin, Margherita, Buscarinu, Maria Chiara, Gagliardi, Maria, Fronza, Marzia, Del Sette, Massimo, Scialabba, Matteo, Bedognetti, Michele, De Rossi, Nicola, Bigi, Rachele, Dubbioso, Raffaele, Reniè, Roberta, Iodice, Rosa, Fabbri, Sabrina, Rasia, Sarah, Parodi, Sergio, Rolla, Simona, Platzgummer, Stefan, Maria Laura, Stromillo, Tassinari, Tiziana, Carlini, Valentina
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Viral Antibody Formation Antibody response anti‐CD20 Autoimmune diseases booster dose CD20 antigen COVID-19 COVID-19 - prevention & control COVID-19 Vaccines Empirical analysis fingolimod Fingolimod Hydrochloride Health risks Humans Immune response Immune response (humoral) Immune system Immunosuppressive agents Multiple sclerosis Multiple Sclerosis - drug therapy Observational studies Prospective Studies Rituximab Rituximab - therapeutic use SARS-CoV-2 SARS‐CoV‐2 vaccine Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Vaccination Vaccines Viral diseases
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Zusammenfassung:	Background and purpose Although two doses of COVID‐19 vaccine elicited a protective humoral response in most persons with multiple sclerosis (pwMS), a significant group of them treated with immunosuppressive disease‐modifying therapies (DMTs) showed less efficient responses. Methods This prospective multicenter observational study evaluates differences in immune response after a third vaccine dose in pwMS. Results Four hundred seventy‐three pwMS were analyzed. Compared to untreated patients, there was a 50‐fold decrease (95% confidence interval [CI] = 14.3–100.0, p
ISSN:	1351-5101 1468-1331
DOI:	10.1111/ene.15830