Reduced dietary Ca, Cu, Zn, Mn, and Mg bioavailability but increased Fe bioavailability with polyethylene microplastic ingestion in a mouse model: Changes in intestinal permeability and gut metabolites
Microplastics emerge as a new environmental and human health crisis. Minimal research exists on effects of microplastic ingestion on the oral bioavailability of minerals (Fe, Ca, Cu, Zn, Mn, and Mg) in the gastrointestinal tract via impacting intestinal permeability, mineral transcellular transporte...
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Veröffentlicht in: | The Science of the total environment 2023-08, Vol.885, p.163853-163853, Article 163853 |
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Zusammenfassung: | Microplastics emerge as a new environmental and human health crisis. Minimal research exists on effects of microplastic ingestion on the oral bioavailability of minerals (Fe, Ca, Cu, Zn, Mn, and Mg) in the gastrointestinal tract via impacting intestinal permeability, mineral transcellular transporters, and gut metabolites. Here, mice were exposed to polyethylene spheres of 30 and 200 μm (PE-30 and PE-200) in diet (2, 20, and 200 μg PE g−1) for 35 d to determine the microplastic effects on mineral oral bioavailability. Results showed that for mice fed diet amended with PE-30 and PE-200 at 2–200 μg g−1, Ca, Cu, Zn, Mn, and Mg concentrations in the small intestine tissue were 43.3–68.8 %, 28.6–52.4 %, 19.3–27.1 %, 12.9–29.9 %, and 10.2–22.4 % lower compared to control mice, suggesting hampered bioavailability of these minerals. In addition, Ca and Mg concentrations in mouse femur were 10.6 % and 11.0 % lower with PE-200 at 200 μg g−1. In contrast, Fe bioavailability was elevated, as suggested by significantly (p |
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ISSN: | 0048-9697 1879-1026 |
DOI: | 10.1016/j.scitotenv.2023.163853 |