Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice

Ketogenic diet ameliorates autism spectrum disorders-like behaviors via reduced inflammatory factors and microbiota remodeling in BTBR T+ Itpr3tf/J mice

Autism Spectrum Disorder (ASD) is increasing, but its complete etiology is still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechan...

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Veröffentlicht in:Experimental neurology 2023-08, Vol.366, p.114432-114432, Article 114432
Hauptverfasser: Olivito, Ilaria, Avolio, Ennio, Minervini, Damiana, Soda, Teresa, Rocca, Carmine, Angelone, Tommaso, Iaquinta, Francesco Salvatore, Bellizzi, Dina, De Rango, Francesco, Bruno, Rosalinda, De Bartolo, Loredana, Alò, Raffaella, Canonaco, Marcello, Facciolo, Rosa Maria
Format: Artikel
Sprache:eng
Schlagworte:
Inflammatory factors
Microbial community diversity
Oxidative stress
Three-chamber sociability
Tumor necrosis factor alpha
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Zusammenfassung:Autism Spectrum Disorder (ASD) is increasing, but its complete etiology is still lacking. Recently, application of ketogenic diet (KD) has shown to reduce abnormal behaviors while improving psychological/sociological status in neurodegenerative diseases. However, KD role on ASD and underlying mechanism remains unknown. In this work, KD administered to BTBR T+ Itpr3tf/J (BTBR) and C57BL/6J (C57) mice reduced social deficits (p = 0.002), repetitive behaviors (p 
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2023.114432