Immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: A meta-analysis

Immunoinflammatory and oxidative alterations in subjects with schizophrenia under clozapine: A meta-analysis

Clozapine presents immunoregulatory properties not well understood. To address this issue, we performed this systematic review to evaluate the immune alterations induced by clozapine and its relationship with the drug's clinical response and compare it with other antipsychotics. Our systematic...

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Veröffentlicht in:European neuropsychopharmacology 2023-08, Vol.73, p.82-95
Hauptverfasser: Martins, Paulo Levi Bezerra, Moura, Ian Araújo, Mendes, Gabrielle, Ribeiro, Vitória Cristina Almeida Flexa, Arnaud, André, Gama, Clarissa S., Maes, Michael, Macedo, Danielle S., Pinto, Joel Porfirio
Format: Artikel
Sprache:eng
Schlagworte:
Clozapine
Compensatory Immune Response System
Cytokines
Inflammatory Response System
Meta-analysis
Psychotic disorders
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Zusammenfassung:Clozapine presents immunoregulatory properties not well understood. To address this issue, we performed this systematic review to evaluate the immune alterations induced by clozapine and its relationship with the drug's clinical response and compare it with other antipsychotics. Our systematic review has selected nineteen studies meeting the inclusion criteria, from which eleven were included in the meta-analysis, totalizing 689 subjects distributed over three different comparisons. The results revealed that clozapine treatment activates the compensatory immune-regulatory system (CIRS) (Hedges's g = +1.049; CI +0.62 – +1.47, p 
ISSN:0924-977X
1873-7862
DOI:10.1016/j.euroneuro.2023.04.003